We have described a patient suffering from LYC with impairment of cellular-mediated immunity. Skin tests for delayed hypersensitivity with PPD, SK-SD and mumps vaccine were negative. In vitro stimulation of lymphocytes with Con A and PWM were depressed, though PHA stimulation and the number of T and В lymphocytes was normal. These results indicate a functional cellular defect which is in agreement with the observations of Hammar and Gortner.
In 1972 Liebow et al described a number of patients with a condition they called lymphomatoid granulomatosis (LYG) of the lung. Since then, other authors have described patients with this entity which is characterized by vasculitis with lymphoreticular infiltrate. Patients with this disease usually seek medical attention because of cough, excess sputum production, fever, dyspnea and weight loss. The pulmonary lesions tend to be in the lower lung fields, may be cavitary, and are generally unassociated with hilar lymphadenopathy. While most of the cases described in the literature have been treated with steroids alone or in combination with cytotoxic drugs, the efficacy of this treatment has not been established.
We report a patient with LYG with impaired cell-mediated immunity. The patient has remained stable without specific treatment for the last eight years.
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